Dapagliflozin – structure, synthesis, and new indications
نویسندگان
چکیده
Dapagliflozin is a sodium-glucose co-transporter-2 (SGLT2) inhibitors used in the treatment of patients with type 2 diabetes. An aryl glycoside significant effect as glucose-lowering agents, also has indication for Heart Failure and Chronic Kidney Disease. This review examines structure, synthesis, analysis, structure activity relationship uses product. The studies behind this drug have opened doors new line – that reduces blood glucoses, decreases rate heart failures, positive on chronic kidney disease.
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Dapagliflozin
Dapagliflozin, a selective inhibitor of the sodium glucose co-transporter type 2 (SGLT2) is in development for type 2 diabetes mellitus with Bristol-Myers Squibb and AstraZeneca. It is currently undergoing phase III development worldwide with regulatory submissions expected in the second half of 2010. This review looks at the development history and scientific profile of this drug to date.
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ژورنال
عنوان ژورنال: ????????
سال: 2021
ISSN: ['2411-6076', '2709-135X']
DOI: https://doi.org/10.3897/pharmacia.68.e70626